Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.
نویسندگان
چکیده
Enhancement of intestinal IgA responses is a primary strategy in the development of oral vaccine. Dietary fatty acids are known to regulate host immune responses. In this study, we show that dietary palmitic acid (PA) and its metabolites enhance intestinal IgA responses. Intestinal IgA production was increased in mice maintained on a PA-enriched diet. These mice also showed increased intestinal IgA responses against orally immunized Ag, without any effect on serum Ab responses. We found that PA directly stimulates plasma cells to produce Ab. In addition, mice receiving a PA-enriched diet had increased numbers of IgA-producing plasma cells in the large intestine; this effect was abolished when serine palmitoyltransferase was inhibited. These findings suggest that dietary PA regulates intestinal IgA responses and has the potential to be a diet-derived mucosal adjuvant.
منابع مشابه
I-9: Sperm Trans Fatty Acids: An Undertreated Issue in Men Infertility
Background: Mammalian spermatozoa are characterized by a high proportion of polyunsaturated fatty acids (PUFA) and the membrane structure of spermatozoa plays a crucial role in fertilization. Moreover, dietary fatty acid (FA) influence sperm FA profiles in several species. This study focused on responses to dietary omega-3 fatty acids and comprehensive fatty acid profiles analysis in men as wel...
متن کاملپاسخ متفاوت سلولهای قلبی به اسیدهای چرب اشباع و غیر اشباع
Introduction & Objective: The link between dietary fat and coronary heart disease has attracted much attention since the effect of long?chain fatty acids (LCFA) on gene transcription has been established, which in part, these effects can be explained by the regulation of gene transcription. In this study, the P19CL6 cardiac cell?line was targeted for the investigation of (i) the effects of long...
متن کاملDietary Triacylglycerols with Palmitic Acid in the sn-2 Position Modulate Levels of N-Acylethanolamides in Rat Tissues
BACKGROUND Several evidences suggest that the position of palmitic acid (PA) in dietary triacylglycerol (TAG) influences different biological functions. We aimed at evaluating whether dietary fat with highly enriched (87%) PA in sn-2 position (Hsn-2 PA), by increasing PA incorporation into tissue phospholipids (PL), modifies fatty acid profile and biosynthesis of fatty acid-derived bioactive li...
متن کاملBeneficial effects of a sodium butyrate source on growth performance, intestinal bacterial communities, digestive enzymes, immune responses and disease resistance in rainbow trout (Oncorhynchus mykiss)
The aim of the present study was to investigate the effects of dietary sodium butyrate on growth performance, intestinal microbiota, digestive enzymes, humoral immune responses and resistance against Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss) juveniles (39.5±1.12 g). The fish were fed diets supplemented with 0 (SB0), 1.5 (SB1.5), 2.5 (SB2.5) and 5 (SB5.0) g/kg sodium butyrate f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of immunology
دوره 193 4 شماره
صفحات -
تاریخ انتشار 2014